Cleanup required after upgrade from 16.04 LTS to 18.04 LTS?

Hello all,

A week or two ago I my upgraded my old laptop from 16.04 LTS to 18.04 LTS by following the directions in the 18.04 final release announcement (Ubuntu MATE 18.04 LTS Final Release | Ubuntu MATE). It all went swimmingly except for a bit of cognitive dissonance near the end when I was notified that some largish number of installed packages are no longer supported by Canonical, but that I could still find support in the community. Since then I've also been notified when apt-getting things that:

The following packages were automatically installed and are no longer required:
apt-xapian-index gir1.2-gmenu-3.0 libgnome-menu-3-0
libqt4-help libqt4-scripttools libqt4-test
libqtassistantclient4 libxapian30 python-apt
python-aptdaemon python-aptdaemon.gtk3widgets
python-attr python-automat python-bs4 python-click
python-colorama python-constantly python-cups
python-debian python-defer python-dirspec
python-html5lib python-httplib2 python-hyperlink
python-incremental python-lxml python-olefile
python-pam python-pil python-piston-mini-client
python-pyasn1 python-qt4 python-qt4-dbus
python-serial python-sip python-twisted-bin
python-webencodings python-xapian
python-zope.interface python3-blinker python3-jwt
python3-oauthlib python3-piston-mini-client
python3-xapian software-center-aptdaemon-plugins
Use 'sudo apt autoremove' to remove them.

I did a bit searching around and discovered the ubuntu-support-status command which tells me:

You have 661 packages (27.6%) supported until April 2021 (Community - 3y)
You have 1605 packages (66.9%) supported until April 2023 (Canonical - 5y)
You have 2 packages (0.1%) supported until April 2021 (Canonical - 3y)

You have 2 packages (0.1%) that can not/no-longer be downloaded
You have 128 packages (5.3%) that are unsupported

So I'm feeling there must be some cleanup required, but I don't want to break anything. Did I miss a step? Is this normal? Can I safely just do sudo apt autoremove, and is that all that's required? It's been a long while since I've done anything but a fresh install of a Linux distro and I'm afraid I don't know what the best practices are. Thanks for any help, and thanks to everyone involved in maintaining this great distro!

You should be safe to sudo apt autoremove as recommended by apt

Thanks. I did that and still have 122 unsupported packages, but then I read this:

and this:

And now I realize that "unsupported" just means the packages are no longer in the main or restricted repositories, and this really isn't a big thing.