Both the Enable Indicators and the Enable Advanced Menu in Mate Tweak under the Interface tab are disabled and I can’t set them on. Why is that and how can I activate these options back on?

I think it’s intentional the option is greyed out. Changing panel layouts (and toggling checkboxes) assume a stock “unmodified” panel and any change ends up replacing the existing layout for that stock panel with those desired options. After saving a custom panel, it could have been radically cus…