System font question

I am looking to delete fonts through font manager and like everyone I have many fonts for languages that I do not write or speak. Can system fonts be safely deleted or will it destabilise things?

Yes, they can.
Please, have a look at

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Unused fonts can be fully removed via the Synaptic package manager.

I do not understand why Ubuntu (and not only ubuntu-mate) install so much fonts that does not have any link with the language choices made in the install process...