Unable to left click on Desktop Icons

Has anyone who elects to have icons on there desktop run into the problem where you cannot left click them? This happens periodically; I thought it was just after coming out of sleep/screen saver, but it started happening even when I am doing work.

I have found a work around to fix the problem. Since my main display is touch screen I am able to left click the home icon and then voila! I am able to left click with my mouse again.