Your Opinion on the Pre stuff for a speedy OS

This is one of the first things I do after installing a system. The other is to set noatime in fstab for pretty much all other partitions except swap.

Zswap I find no use for, since most of my machines have enough RAM to avoid swapping in the first place.

One thing to add: if you have "enough" RAM and use Firefox, moving profile (not cache!) to tmpfs speeds up things noticeably. I rolled my own, but from my Arch days I remember there are ready made scripts for this. The trick, of course, is to automate the tmpfs mount and umount + set up a cron to back up profile to disk periodically.

Edited to add:
Discussion on the topics "/tmp to tmpfs" and "Firefox profile to tmpfs" continues here:
Some questions about /tmp to tmpfs

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