Clean /usr/local/include?

Hello!

I have many files under "/usr/local/include" some of which are no longer needed because my compiled programs have been removed.

Now I don't know how to find out which packages these files still belong to.

Is it safe to clean "/usr/local/include"?

I looked in the Ubuntu Live DVD, the folder "/usr/local/include" is empty.

How can I find out to which installed/removed packages these files under "/usr/local/include" belong?

Here's my lst from: "/usr/local/include"

/usr/local/include/crypto
/usr/local/include/curl
/usr/local/include/dnet
/usr/local/include/event2
/usr/local/include/gpgme++
/usr/local/include/libnetfilter_queue
/usr/local/include/libnfnetlink
/usr/local/include/llvm
/usr/local/include/llvm-c
/usr/local/include/nettle
/usr/local/include/openssl
/usr/local/include/oqs
/usr/local/include/qgpgme
/usr/local/include/QGpgME
/usr/local/include/assuan.h
/usr/local/include/dnet.h
/usr/local/include/evdns.h
/usr/local/include/event.h
/usr/local/include/evhttp.h
/usr/local/include/evrpc.h
/usr/local/include/evutil.h
/usr/local/include/gcrypt.h
/usr/local/include/gpg-error.h
/usr/local/include/gpgme.h
/usr/local/include/gpgrt.h
/usr/local/include/ksba.h
/usr/local/include/npth.h
/usr/local/include/ntbtls.h

Have now found out some things after a long search.

REMOVED: 'folder'

/usr/local/include/dnet # dnet
/usr/local/include/event2 # libevent
/usr/local/include/gpgme++ # gpgme
/usr/local/include/llvm # llvm
/usr/local/include/llvm-c # llvm
/usr/local/include/nettle # nettle-dev?
/usr/local/include/oqs # open-quantum-safe/liboqs
/usr/local/include/qgpgme # gpgme
/usr/local/include/QGpgME # gpgme

REMOVED: 'files'

/usr/local/include/assuan.h # gpgme
/usr/local/include/dnet.h # dnet
/usr/local/include/evdns.h # libevent
/usr/local/include/event.h # libevent
/usr/local/include/evhttp.h # libevent
/usr/local/include/evrpc.h # libevent
/usr/local/include/evutil.h # libevent
/usr/local/include/gpgme.h # gpgme
/usr/local/include/gpgrt.h # gpgme
/usr/local/include/ksba.h # libksba-dev

Can't really find anything on this:

/usr/local/include/gcrypt.h # ?
/usr/local/include/gpg-error.h # ?
/usr/local/include/npth.h # libnpth0-dev
/usr/local/include/ntbtls.h # ?

First of all you should know that /usr/local is not controlled by packages manager.
So here you have some files and folders of locally compiled or installed stuff.
You should remind yourself when and why you had installed stuff here.
Then you can do any cleanup here.