How do I make net configuration persistent over boots

When I boot my RP4 with 21.10 it wants to get its net configuration from dhcp. I want to use static configuration so I go to the net configuraion utility in the panel and choose "Edit Connections...". There I choose "netplan-eth0" and go to the tab marked "IPv4 Settings". There I choose "Method" "Manual" and fill in all the information. When I click "Save" everything works well except on next boot I have to enter the configuration again.

How can I make it remeber what I tell it?