I'm coming from ubuntu to this distro, and so far i think the front-end experience makes ubuntu's design decisions look like an absolute joke, it has all the basic things that ubuntu lacked and i found myself having to tweak my system far less to get it to how i like it in comparison to ubuntu, on top of that mate doesn't seem to be a crashy memory hog like gnome.
However there was one thing i didn't like and that was middle mouse button emulation was enabled by default, i was playing world of warcraft and i usually move/steer with both of my L/R (left/right) mouse buttons held down while moving my mouse, my middle mouse button was the button to toggle auto-run, so i found myself auto-running every time i held down both L/R, which was very strange.
I thought this was an issue with my game, but about an hour and 30 minutes later, i had found out it was because ubuntu mate, by default is configured to press middle mouse if you press both L/R at the same time which is known as middle mouse button emulation, and i don't like that because it can interrupt peoples games, i definitely think it should be an optional feature that can be turned on, but i don't agree with it being turned on by default.
It's a very minor gripe of mine, overall i think this distro is really just a great polished, proper end-user version of what ubuntu is supposed to be and the ubuntu mate team seems to actually listen (unlike canonical), so that's why i thought i would put in my two cents.