I just reported this bug here:
a couple of minutes after boot, the touchpad stops responding (can't move the pointer, but the buttons are still responsive)
Machine: Thinkpad T460s
Kernel: 5.8.0-23-generic #24-Ubuntu
OS: Mate 20.10 beta
The Trackpoint (the nipple in the middle of the keyboard) and external mouse continue to function. The trackpoint however, moves much slower than usual.
lightdm.service fixes the problem temporarily. However, shortly after logging back in the touchpad stops responding again.