There is a command-line tool called xsetwacom exactly for this purpose. Please read more about its capabilities by checking the manual page for it: man xsetwacom.
To answer your dual-monitor question specifically, I just happened to be researching Wacom tablets myself and came across this blog post for a different Wacom tablet model:
The stuff pertaining to multi-monitor setups is in the second half of the article. It appears that much of the content holds true for other Wacom tablets as well, though understand that I haven't tried the directions in the post myself yet (I don't have the money for a second monitor).
Good luck!